From a surgical point of view, especially in micro-vascular surgical fields, thromboembolism has been, and still is, a dreaded postoperative complication.
Author administrated Urokinase, Aspirin or Urokinase plus Aspirin concomitantly to the patients who was undertaken microvascular anastomosis and studied serum fibrinogen concentration, platelet count, hematocrit and bleeding time preoperatively and on postoperative 1st, 2nd, 3rd, 4th and 14th days.
Analyzing the above results stastically, author obtained following results.
1. Postoperatively fibrinogen concentration increased in all groups due to stress in the form of trauma, hemorrage and anesthesia, peak on postoperative 3rd day.
2. Decrease rate of fibrinogen concentration was definite in Urokinase administrated group (p〈0.001) and Urokinase plus Aspirin administrated (p〈0.01) compare to control group.
3. There was no definite difference in fibrinogen concentration decrease between Urokinase plus Aspirin administrated group and Urokinase alone administrated group or Aspirin alone administrated group.
4. Bleeding time was prolonged in Aspirin administrated group and Aspirin plus Urokinase administrated group.
5. Platelet count change was proportional to hematocrit change in all groups except Urokinase administrated group (p〈0.05).
6. Lowering the fibrinogen concentration, Urokinase has definite preventive effect on thromboembolism, rather than thrombolytic effect, in micro-vascular surgical fields.
|